Gigantol ( 5-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol)
Gigantol(Dendrophenol)
CAS: 67884-30-4
Molecular Formula: C16H18O4
Gigantol ( 5-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol) - Names and Identifiers
Gigantol ( 5-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol) - Physico-chemical Properties
| Molecular Formula | C16H18O4 |
| Molar Mass | 274.31 |
| Density | 1.204±0.06 g/cm3(Predicted) |
| Melting Point | 95-96°C |
| Boling Point | 454.1±40.0 °C(Predicted) |
| Solubility | DMSO : ≥ 100 mg/mL (364.55 mM) |
| Appearance | Liquid |
| pKa | 9.63±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD11100326 |
| Physical and Chemical Properties | White crystals, soluble in methanol, ethyl acetate, almost insoluble in water, from Dendrobium nobile. |
| In vitro study | Gigantol decreases the level of phosphorylated LRP6 and cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with gigantol reduces the level of phosphorylated LRP6. Gigantol significantly inhibits the proliferation and induces apoptosis of the HepG2 cells. Gigantol at concentrations of 1, 40 and 150 µM markedly decreases the cell viability by 11.7, 30.0 and 56.4% at 24 h and 21.1, 66.8 and 85.5% at 48 h, respectively. The IC 50 value is 9.30 µM. |
| In vivo study | LDD and gigantol (25–100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice and decreased carrageenaninduced inflammation in rats. |
Gigantol ( 5-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol) - Reference
| Reference Show more | 1. Zhang Mei, Li Chunxia, Wei Fang, et al. Protective effect of Dendrobium on human retinal microvascular endothelial cells induced by high glucose [J]. International Journal of Ophthalmology, 2019, 19(02):40-44. 2. Fan Zhao-Yang, Xian Wen-feng, Liu Yong-Xi, et al. Dendrobium phenol inhibits proliferation, migration and invasion of osteosarcoma cells through NF-κB/PRL-3 pathway [J]. Chinese Journal of tumor Biotherapy, 2019, 26 (10). 3. Yu, Shubin, et al. Gigantol inhibitors Wnt/β-catenin signaling and exhibits activity in breast cancer cells."BMC complete and alternative medicine 18.1 (2018): 1-8.https:// doi.org/10.1186/s12906-018-2108-x 4. [IF = 3.659] Yu Shubin et al."Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells."Bmc Complem Altern M. 2018 Dec;18(1):1-8 5. [IF=5.037] Jiahui Huang et al."Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway."Life Sci. 2021 Jun;274:119354 |
Gigantol ( 5-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol) - Reference Information
| biological activity | Gigantol is a bibenzyl compound from several medicinal orchid species. Gigantol has anti-tumor activity. Gigantol is an inhibitor of the Wnt/β-catenin pathway. |
| Target | Wnt |
| uses | Dendrobium phenol has the effects of Immunoregulation, antitumor, hypolipidemic and hypoglycemic. for content determination/identification/pharmacological experiments. |
Last Update：2024-04-09 02:00:09
![Gigantol ( 5-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol)](http://res.chembk.com/assets/str/2d/6/67/67884-30-4.png)
Supplier List
Spot supply
Product Name: Gigantol(Dendrophenol) Request for quotationCAS: 67884-30-4
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: Gigantol(Dendrophenol) Request for quotationCAS: 67884-30-4
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Product Name: Gigantol(Dendrophenol) Request for quotation
CAS: 67884-30-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 67884-30-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: Gigantol isomer-1 Visit Supplier Webpage Request for quotationCAS: 67884-30-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Gigantol Visit Supplier Webpage Request for quotationCAS: 67884-30-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Gigantol Visit Supplier Webpage Request for quotationCAS: 67884-30-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Gigantol Visit Supplier Webpage Request for quotationCAS: 67884-30-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Gigantol(Dendrophenol) Request for quotationCAS: 67884-30-4
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: Gigantol(Dendrophenol) Request for quotationCAS: 67884-30-4
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Product Name: Gigantol(Dendrophenol) Request for quotation
CAS: 67884-30-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 67884-30-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: Gigantol isomer-1 Visit Supplier Webpage Request for quotationCAS: 67884-30-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Gigantol Visit Supplier Webpage Request for quotationCAS: 67884-30-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Gigantol Visit Supplier Webpage Request for quotationCAS: 67884-30-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Gigantol Visit Supplier Webpage Request for quotationCAS: 67884-30-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History